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It has emerged autoimmunity particularly overt in cystic fibrosis mice lacking invariant natural killer T (iNKT) cells which play a role to control autoimmune diseases triggered by a ceramidemediated induction of cell death in CF, and although suppression of the autoimmune response by iNKT cells is beneficial, IL 17 + iNKT cells attract macrophages and neutrophils to CF lungs resulting in chronic inflammation

Over four decades of research, Khavinson's group has characterized a class of short peptides (2-4 amino acids) that they propose regulate gene expression in specific target tissues, offering a targeted approach to age-related functional decline

Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions

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Malar J 20(1):57 Singh R, Chopra S, Graham C, Langer M, Ng R, Ullal AJ, et al (2020) Emerging approaches for fluorescence-based newborn screening of mucopolysaccharidoses