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The role of ferroptosis in endothelial cell dysfunction

37 , 723741.e6 (2025)

Rasmus Feistenauer Institution: University Hospital of Wrzburg, Germany Result: Allogeneic MSC infusions significantly decreased anti-U1 RNP titers, suppressed IL-6 and TNF-, and led to clinical remission in patients with overlapping scleroderma and polymyositis features

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Dual inhibition of GGCT and xCT induces ferroptosis through cysteine depletion and redox collapse To investigate the mechanism by which the combination of pro-GA and erastin induces ferroptosis, we assessed whether the mechanism involved disrupting intracellular redox homeostasis