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1 H NMR (400 MHz, Chloroform-d) = 9.30 (d, J = 5.7 Hz, 1H), 8.50 (d, J = 7.9 Hz, 1H), 8.21 8.07 (m, 3H), 7.69 (t, J = 6.8 Hz, 1H), 7.09 (dd, J = 9.3, 4.7 Hz, 2H), 6.17 (d, J = 6.3 Hz, 1H), 5.85 (dd, J = 15.4, 6.5 Hz, 2H), 5.69 (d, J = 6.3 Hz, 1H), 4.37 4.28 (m, 2H), 3.92 (s, 2H), 2.50 (s, 3H), 2.33 2.21 (m, 1H), 2.14 (p, J = 6.1 Hz, 2H), 1.08 (d, J = 6.9 Hz, 3H), 0.99 (d, J = 6.9 Hz, 3H)

Impaired Detoxification : Lower glutathione levels can hinder the bodys detoxification processes, making it more challenging to eliminate toxins and waste products

421,422,423,424 Several studies have shown abnormal intracellular iron distribution in Friedreichs Ataxia, with elevated serum transferrin receptor levels in patients

Abbreviations: BSO, buthionine sulfoximine

Briefly, GDF15 and DDIT3 were both significantly upregulated 1.9-fold following PQ challenge and were modulated with L-NAC (1.4- and 1.5-fold, resp.), but not NAC (2.0- and 2.2-fold, resp.), pretreatment