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Two metal ions, iron (Fe) and copper (Cu) are essential factors leading to RCDs that not only induce ferroptosis and cuproptosis, respectively but also lead to cell impairment and eventually diverse cell death

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Mechanistically, HNE inhibited the NLRP3 inflammasome activation independently of Nrf2 and NF-B signaling, and had no effect on the AIM2 inflammasome

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