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In the locus coeruleus of young rats, those opioid peptides produce heterologous MOR desensitization with 2 adrenoreceptors in a GRK2-dependent manner but independently of its kinase activity

SMD is a universal solvation model, where "universal" denotes its applicability to any charged or uncharged solute in any solvent or liq

Owing to its high concentration in the cell (~10 3 M) 1 , the GSH/GSSG pair acts as the main intracellular redox buffer, plays a key role in the detoxification of reactive oxygen species (ROS), and participates in redox signalling 2

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Also, Steppogenin is a natural flavanone with a strong tyrosinase inhibitory activity (IC 50 = 0.98 0.01 M), from Morus alba L 249