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Metabolic dysfunctionassociated steatohepatitis (MASH, formerly nonalcoholic steatohepatitis, NASH) is a major research focus, characterized by excessive hepatic fat accumulation, inflammation, and hepatocellular injury

Mice tolerated doses several times higher than the effective dose with no observable adverse effects

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Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

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