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Probiotics such as Bifidobacterium pseudocatenulatum can increase fecal DCA/LCA, suppressing Th1/Th17 responses via TGR5 in arthritis models (79)

doi: 10.1080/13510002.2024.2445398 43 ZhangYHuMJiaWLiuGZhangJWangBet al

Higher doses may be considered under clinical supervision for those who decline injections despite malabsorption, though this is an off-label approach

Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity

However, the majority of them may still induce certain undesirable effects, including stomatitis, hyperlipidemia, rash, myelosuppression, and hyperglycemia [125]

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