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Systematic reviewGLP-1 class evidence2025 Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference A broad meta-analysis anchor for GLP-1 weight-loss effect and class-level comparisons

doi:10.1038/s41575-021-00440-6 Ananda Rao A, Johncy S

2.4 mg (CagriSema s.c

Interindividual variability further complicates research, as aging and sleep patterns differ widely among individuals, making it difficult to generalize findings and establish universal mechanisms

Studies show carnitine deficiencythough rare in healthy adultscorrelates with reduced exercise-induced fat loss and slower metabolic adaptation

Theyre commonly taken as supplements or used in topical products to support skin and joint health