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The moderated t-statistics of differential expression was computed by empirical Bayes (eBayes), using a linear model fit (Lmfit) and comparing the overall effect of intervention over control using the following equation: (Intervention.T2Intervention.T1)(Control.T2Control.T1), where T2 is the time point after the 6 weeks of intervention (MV4) and T1 is the time point of the first visit (MV1)

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Mouse primary epidermis was isolated from 12 day old wild type and C/EBP knockout B6N:129 hybrid mouse skin by flotation in Hanks Balanced Salt Solution (H9394, Sigma-Aldrich) and 0.25% trypsin (15090-046, Life Technologies) (Sterneck et al., 1997

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