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MOTS-c appears to be one of the most potent natural activators of this cascade [1]

[Google Scholar] 35.Kurpad A.V., Pasanna R.M., Hegde S.G., Patil M., Mukhopadhyay A., Sachdev H.S., Bhat K.G., Sivadas A., Devi S

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Reduced inflammation prevents premature transition to catagen

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Vitamin B12 is a water-soluble vitamin which means any excess will be urinated out of your body (assuming you have normal kidney function), so the risk of overdose is basically non-existent