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Future studies should explore means of restoring BBB integrity, which could extend scientific knowledge and contribute to novel therapeutic targets

GSH brain concentrations are not commonly measured using 1 H-MRS, because relative to other 1 H-MRS-detectable neurochemicals (e.g., creatine (Cr), choline, N -acetylasparate), GSH concentrations are substantially lower

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The clinical implications, however, depend on whether the mechanism translates to humans and whether the doses used produce meaningful c-Met activation in human brain tissue

Microscopic examination found no changes in liver, spleen, lung, kidney, brain, thymus, or reproductive organs

Autor: mag