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This could be because oxidative stress causes an ovarian inflammatory and apoptotic microenvironment, which in turn inhibits and/or shuts off the ovarian steroidogenesis pathway 57,58

: Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial Mehri Jamilian et al

Thus, substantial evidence indicates that elevated TMAO levels are associated with cardiovascular disease (CVD)

ALA has also been suggested to inhibit renal and vascular overproduction of endothelin-1, a vasoconstrictor produced by the endothelium [84]

M., Nair G., et al

Novo Nordisk, Inc
