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Methotrexate associated to lipid core nanoparticles improves cardiac allograft vasculopathy and the inflammatory profile in a rabbit heart graft model

The analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was carried out using Enrichment tool of MetaboAnalyst

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doi:10.1186/s12872-025-05186-6 Shaikh S, Hamza M, Neppala S, et al

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Oxidative damage extends beyond the acute phase, disrupting the BBB, impairing vascular integrity, and activating inflammatory cascades that perpetuate secondary injury
