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In support of this mechanism, many natural products, including resveratrol as an allosteric activator of SIRT1 [349] and curcumin [350], have been shown to induce cardioprotective effects by activating SIRT1

10.1016/j.yjmcc.2017.11.006 41 ZhangS.LiuX.Bawa-KhalfeT.LuL

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Falta de Estudios en Humanos Aunque los resultados en animales son prometedores, hay un gran inconveniente: no hay suficientes estudios clnicos en humanos