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A pharmacist or health practitioner is authorized to administer the first dose of the B12 injections in Ontario, for the purpose of education and demonstration

at a dose of 500 g twice a week, 56 a dose lower than in most other trials

Study design: hormone-manipulation protocol Throughout the six-month protocol, each participant received monthly injections of the GnRH agonist depot leuprolide acetate (Lupron, 3.75 mg IM), which suppresses the ovarian secretion of estradiol and progesterone

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