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Clinical trials have shown that GDNF does not significantly improve motor symptoms in PD patients and is associated with a higher incidence of serious adverse events (179)

As for multifactorial therapies, like platelet - rich plasma (PRP) or exosomes, several challenges exist, including high costs, the risk of immune reactions from allogeneic injections, and difficulties in ensuring the homogeneity of the therapy

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In MEN1 syndrome, PRLomas are the most common pituitary-related manifestation (228, 230)