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Lazic et al., 2020)

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doi: 10.1155/2017/8416763 171 AcevesCAnguianoBDelgadoG

A study showed that when Nrf2 is absent in mice, astrocyte activation increases, and NF-B signaling pathways are modulated, causing nerve damage and an inflammatory response [126]

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A broader 2024 review on cartilage engineering peptides highlighted AOD 9604 as a candidate that, in preclinical models, may support cartilage matrix restoration when delivered intra-articularly in OA settings