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reported that GPX3 protein levels in ALS model rats carrying the mutant superoxide dismutase-1 (SOD1) H46R initially increased during the pre-symptomatic stage but decreased as the disease progressed [187]

H., Shyue, S
There are lab studies that show possible mechanisms

It plays a central role in the two phases of liver detoxification

Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide

In compounded form, the cost difference is more manageable
