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Abbreviations BBB: Bloodbrain barrier CNS: Central nervous system FMO: Frontier molecular orbital GPx4: Glutathione peroxidase 4 MD: Molecular dynamic MM/GBSA: Molecular mechanics with generalized Born and surface area solvation MolSA: Molecular surface area MS: Multiple sclerosis PSA: Polar surface area QSAR: Quantitative structureactivity relationship rGyr: Radius of gyration RMS: Root mean squared RMSD: Root mean square deviation RMSF: Root mean square fluctuation SASA: Solvent accessible surface area References B.K.T

[DOI] [PMC free article] [PubMed] [Google Scholar] 270.Dahl H., Degre M

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Additionally, cytochrome B5 reductase (CYB5R1) and cytochrome P450 reductase (POR) contribute to the process of ferroptosis by accelerating the peroxidation of phospholipids (Zou et al., 2020b)

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doi: 10.1186/S12937-025-01193-7 119
