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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

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However, recent studies have shown that inflammatory changes can lead to central sensitization and chronic pain [17]

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Development and clinical application of a LCMS/MS method for simultaneous determination of various tyrosine kinase inhibitors in human plasma

C., Purohit, S