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There was a trend for colorectal cancer cell lines carrying KRAS mutation (HCT-15, HCT116, DLD-1, LoVo and SW480) to be more resistant to serine and glycine withdrawal compared to those cell lines carrying BRAF mutations (RKO, HT-29, SW1417 and CL-34), although SW620 (KRAS mutant) and VACO5 (BRAF mutant) were exceptions to this trend (Fig

Obeticholic acid modulates serum metabolites and gene signatures characteristic of human NASH and attenuates inflammation and fibrosis progression in Ldlr-/-.Leiden mice

Schmued, L

Genetic knockout models provided robust reverse validation: In Nrf2-KO mice, the neuroprotective effects of Tripterygium wilfordii extract nearly disappeared, indicating a strict dependence on Nrf2 activation

A dioxygen molecule is trapped by this radical to form a peroxyl radical

Other antioxidants, such as catalase or peroxiredoxins, may similarly diminish the effects of ROS on proliferative and survival signaling (53, 154)
