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We also uncovered an unexpected role for CoQ in the transcriptional regulation of pivotal thermogenic genes like UCP1, affecting uncoupled respiration and leading to a rise in the inner mitochondrial membrane potential and a decline in ADP/ATP ratios (Chang et al, 2022)
A minimum score of 5 on the 12-point Symptom Severity Scale (SSS), which combines two measures: 1) severity of fatigue, poor sleep, and cognitive symptoms, and 2) severity of physical symptoms

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Such agents also have important therapeutic uses

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