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The reduction introduces a hydrophilic group in the drug molecule or unmasks the already present hydrophilic group
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[DOI] [PubMed] [Google Scholar] 38.Cobley J.N., Fiorello M.L., Bailey D.M
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The in vivo inhibition of IP6K decreased plasma phosphate levels without inhibiting gut intake or kidney reuptake of phosphate, demonstrating a pivotal role of IP6K-regulated cellular phosphate export on circulating phosphate levels
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