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Trends Biochem Sci 21:383387 Liao X, Butow RA (1993) RTG1 and RTG2: Two yeast genes required for a novel path of communication from mitochondria to the nucleus

These mitochondrial morphological alterationsincluding reduced organelle size, increased membrane density, and cristae disruptionare established ultrastructural hallmarks of ferroptosis and are functionally associated with impaired mitochondrial bioenergetics, including loss of membrane potential, diminished electron transport chain activity, and excessive ROS generation (Figure 2G)

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Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases

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doi: 10.1021/acs.jmedchem.8b00315 23 ForcinaGCDixonSJ