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In rodent and cell work, NNMT knockdown or inhibition has been described as protecting against diet-induced weight gain and improving metabolic measures without reducing food intake [5] [6]

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This enzymatic process results in the depletion of NAM, a precursor of nicotinamide adenine dinucleotide (NAD + ), and the generation of SAH, a precursor of homocysteine (Hcy)

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