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Nonsteroidal anti-inflammatory drugs and aspirin should be avoided, if possible, for patients with cirrhosis and esophageal varices due gastrointestinal bleeding and nephrotoxicity risks

Based on estimates by the National Institutes of Health (NIH), it has been estimated that about 32,000 individuals were carriers of AMS and familial melanoma in the United States in 1985, while about 4 million had sporadic AMS.3,21 Genetics AMS can be sporadic or hereditary, in which case autosomal dominant inheritance is suggested with variable expressivity and incomplete penetrance.22 To date, no susceptibility gene has been identified for this syndrome.22 However, there are reports of associations between development of AMS and changes in chromosomes 9p21 and 1p36

3.2 Reduction in neurotransmitter synthesis Neurotransmitters serve as carriers of synaptic communication and regulate cognitive, emotional, and motor functions by mediating the signal transmission between neurons (40)