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Neurological manifestations are particularly concerning and may include peripheral neuropathy with paresthesias (tingling and numbness in hands and feet), ataxia, impaired proprioception and vibratory sense, cognitive impairment, memory loss, and in severe cases, subacute combined degeneration of the spinal cord

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Methods A PRISMA-compliant systematic review of PubMed/Medline (inceptionJanuary 2026) for case reports/series detailing IGS treatment was conducted

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Purging typically resolves, with improvement following

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