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In this cycle, vitamin B 12 is a necessary cofactor for methionine synthase, an enzyme involved in the methylation of homocysteine to methionine

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Cecal samples Cecal weight was measured since the weight of this portion of the intestine appears to be highly influenced by the microbiome (e.g., certain antibiotic treatments dramatically increase cecal weight 27,28,29,30,31 but not the colon 27 )

I also found myself without an appetite and regularly skipped meals

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