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Phentermine failures can occur because the appetite suppression was insufficient, because tolerance developed too quickly, or because the patient eating patterns were driven by factors other than hunger (emotional eating, habit, environment)

Ziaeifar E, Ziaeifar F, Mozafarpoor S, Goodarzi A

For instance, despite strong preclinical data 185 , trials for oral DCA in stage IIIB/IV non-small cell lung carcinoma and stage IV breast cancer were terminated due to severe safety concerns (NCT01029925) 186

Because healing and tissue repair take time, consistency is often an important part of the process
Benefits of methotrexate use on cardiovascular disease risk among rheumatoid arthritis patients initiating biologic disease-modifying antirheumatic drugs

Thorax 77 (1), 94101
