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Description
Clinical research on T4 is still in progress for several cardiovascular, dermal, and ocular applications

Pende, M

At the cellular level, elevated Hcy disrupts the retinal blood barrier and increases pigment epithelial cell inflammatory cytokines, which cause retinal apoptosis [101]

doi: 10.1046/j.1471-4159.1998.70031009.x 149 McDermottCChess-WilliamsRMillsKKangSFarrSGrantGet al

HO-1:Heme oxygenase 1

thus, it protects endothelial and mitochondrial dysfunction by preventing peroxynitrite formation