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Data from the Euro-Lupus Nephritis Trial show that remission-inducing treatment with a low dose of CYC gives clinical results comparable to those obtained with high-dose treatment but has a better safety profile [51]

Addition of the ISR agonist Sephin1 to cultured human OLmaintained under control conditions or exposed to ongoing metabolic stressreduced process outgrowth 42 , suggesting that the ISR regulates the protein synthesis machinery required for OL process outgrowth and maintenance

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