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Additives : Antioxidants or reducing agents (e.g., DTT) may help, but use cautiously as they can interfere with some assays

Furthermore, this facilitates the secretion of proinflammatory cytokines (e.g., TNF-, IL-1, and IL-6) and attracts immune cells (e.g., macrophages, natural killer cells, and neutrophils), which accelerates stem cell injury and causes vascular endothelial dysfunction, resulting in a vicious cycle that worsens the progression of RE

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doi: 10.1021/bi300752r 21 LawenALaneDJ

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They need comprehensive toxicology testing, detailed genomic risk assessments for virulence and antimicrobial resistance genes, and rigorous phase IIII clinical trials, similar to other LBPs (525)