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Hepatorenal damage: A large number of long-term use, hepatorenal damages and thrombocytopenia may occur, even jaundice, oliguria, acute severe hepatitis, which could lead to coma, and death

Mitochondrial dysfunction, a key feature of AD, further exacerbates ROS production, impairs ATP generation, disrupts calcium homeostasis, and ultimately induces neuronal apoptosis (Bhatt et al., 2021)

Liver failure induced by APAP correlates often with overdose or misusage, including chronic overuse (Lee et al., 2008)

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Lopez-Vergs S, Milush JM, Schwartz BS, Pando MJ, Jarjoura J, York VA, et al

Disulfide cross-linking of urea-insoluble proteins in rabbit lenses treated with hyperbaric oxygen