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Free Radic Biol Med 113: 385394, 2017

10.1164/rccm.201601-0088OC 86

Amantadine Amantadine is a noncompetitive antagonist of the glutamate receptor N-methyl-D-aspartate receptor (NMDAR), exerting both direct and indirect effects on glutamatergic and dopaminergic signaling

the methods of extraction and characterization were described in previous publications (Breyer et al., 2011)

Experiments in vitro showed that ezrin regulates extension of astrocytic philopodia (analogs of leaflets), while in situ astrocytic ezrin expression follows circadian changes in glutamatergic transmission, thus changing synaptic coverage 423

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