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J.KrssakM.KautschitschS.SommergruberW.Tontsch-GruntU.et al (2008)

While it decreases ROS generation by enhancing antioxidant enzyme activity, DPQ has also been associated with detrimental effects, including increased DNA damage and apoptosis in cardiomyocytes 170

However, it is worth noting that there remains a lack of direct experimental evidence to demonstrate the synergistic effects of these pathways in the treatment of hair loss

Thus, targeting key signaling axes related to macrophage polarization such as PI3K/Akt/-catenin, along with interaction pathways with fibroblasts such as P2rx4/IL-6/Arg1, may enable synergistic intervention against this disease

and the Core Laboratory for Medical Research and Education, Kumamoto University School of Medicine for technical support