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Description
Consequently, its rapid metabolism into active fragments and lack of systemic accumulation highlight a strong clearance profile, reducing the potential for peptide build-up or toxicity

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Individuals with a faster metabolic rate may burn through their B12 reserves more quickly, while those with a slower metabolism might retain the vitamin for a longer period

Importantly, NNMT is a dominant component of the gene expression signature for sarcopenia, overexpression of which could lead to significantly reduced levels of NAD+ and associated declines in muscle mass, strength, and function that accompany aging
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NAD+ biosynthesis, aging, and disease
