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Abbreviations BPN: Benign pulmonary nodules PLC: Primary lung cancer HPG: Healthy population group CEA: Carcinoembryonic antigen Cyfra21-1: Cytokeratin 19 fragment NSE: Neuron-specific enolase ProGRP: Gastrin-releasing peptide precursor SCAA: Squamous cell carcinoma antigens PCA: Principal component analysis PLS-DA: Partial least squares discriminant analysis OPLS-DA: Orthogonal partial least squares discriminant analysis Par: Pareto variance scaling VIP: Variable importance in the projection FC: Fold change ROC: Receiver operating characteristic curve AUC: Area under the curve References Sung HA-O et al

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