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Angiogenesis and why blood supply matters Damaged tissue cannot heal without adequate blood supply

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Guanosine triphosphate cyclohydrolase I (GTPCH, EC 3.5.4.16), 6-pyruvoyltetrahydropterin synthase (6-PTPS, EC 4.2.3.12), and sepiapterin reductase (SR, EC 4.1.1.17) are the enzymes for BH 4 biosynthesis
