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10.1016/j.bbabio.2015.04.009 Biochim

In particular, changes in the expression/function of OCTN2 and CT2 have been observed in human cancers indicating that cell supply of carnitine is strictly regulated during cancer development and that chemical KO of these proteins may serve as a strategy to impair energy production from FAO

Abbreviations AMPK: AMP-dependent protein kinase Bcl-2: B-cell lymphoma-2 Bax: Bcl2-Associated X CDK2: Cyclin-dependent kinases 2 C10:2: Decadienyl-l-carnitine ETO: Etomoxir HSP47: Heat shock protein 47 IL-1: Interleukin-1 IL-18: Interleukin-18 MCT: Monocrotaline MMP2: Matrix metallopeptidase 2 MMP9: Matrix metallopeptidase 9 NLRP3: NOD-,LRR-and pyrin domain-containing protein 3 PASMCs: Pulmonary artery smooth muscle cells PCNA: Proliferating cell nuclear antigen PDGF-BB: Platelet-derived growth factor-BB PH: Pulmonary hypertension PVR: Pulmonary vascular remodeling ROS: Reactive oxygen species TGF-: Transforming growth factor References Ruopp NF, Cockrill BA

However, further research is needed to elucidate the underlying mechanisms and establish optimal doses

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