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After 12 weeks of twice-daily application over the entire face, evaluation by visiometry revealed a significant reduction in two skin-roughness parameters (R2 and R3) among the women in the L-carnitine group, reflecting a visible improvement in skin texture and a decrease in wrinkles compared with the placebo
45 Swerdlow AJ, English JS, Qiao Z

Both cholesterol and sphingomyelin are abundant in lipid rafts (12), and cholesterol traps sphingomyelin in nanoscale domains in the plasma membrane (51)

In contrast to the nonmelanocytic epidermal nevus, melanocytic nevi can be situated: (1) at the junction of the epidermis/dermis (junctional)
however, approximately 5% are still present in adulthood, especially those located on the distal extremities