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ACS Appl Mater Interfaces 14(38):4288742903 Cai H, Chen Z, Hu W, Tan W, Wu H, Wang C (2024) Total flavonoids of Salvia miltiorrhiza alleviate acetaminophen-induced acute liver injury in mice by suppressing hepatocyte ferroptosis via activating the Nrf2/HO-1 signaling pathway

doi: 10.1038/nature02046

Conclusions ROS are neither uniformly harmful nor uniformly beneficial

Supplementary information The spectrophotometer is set at a 412-nm wavelength and a continuous reading is performed for a few minutes until a plateau is reached

Free polyunsaturated fatty acids are the substrates of LOXs, which mediate ferroptotic peroxidation (Xie et al., 2016b), can also inhibit LOXs activity in some cases