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Course of the study Female rats were euthanized by injection of sodium pentobarbital

Traditionally, leukemia stem cells (LSC) have been thought to play a major role in drug resistance and disease relapse in chemotherapy treated AML patients (Shlush et al., 2017

Depletion of CYP18A1 in the fat body rendered these Drosophila resistant to APAP-induced mortality (Fig

This limits the dose of drug that can be delivered at one time, requiring that formulations appropriate for intranasal delivery be highly concentrated, soluble and stable to ensure effective dosing within the limited volume