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Most compounds demonstrate systemic bioavailability below 10% when administered in conventional forms, substantially limiting their biological effects (91, 153, 155157)

Numerous studies revealed that cancer is the results of oxidative DNA damage by ROS, in which hydroxylation of bases of DNA molecule take place followed by change in DNA structure

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[PMC free article: PMC4433400] [PubMed: 25712922] 441

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