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& Henske, E

The Leu162Val polymorphism (rs1800206) affects PPAR transcriptional activity: Val allele carriers may demonstrate enhanced fatty acid utilization and ketone generation, while Leu/Leu individuals may experience a more sluggish metabolic shift into ketosis [71,72]

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Likewise, in a recent trial in which participants were randomly assigned, neither they nor the researchers knew who was receiving the treatment and who was receiving the placebo found that administering 1 mg of oral methylcobalamin to individuals with nerve damage due to diabetes treated with metformin for twelve months resulted in enhanced plasma levels of B12 and alleviation of neurophysiological symptoms [53]