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128 They determined the brain-targeting efficiency after intranasal administration of a methotrexate solution (free MTX), methotrexate-loaded ISG (MTX-ISG), methotrexate-loaded niosome (MTX-N), and MTX-N-loaded ISG (MTX-N-ISG)

Proteins are one of the most abundant biomolecules and are a frequent target of ROS attacks

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GLYT1 receptor is present in the basolateral membrane of enterocytes and its main function is to import glycine into the cells

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This suggests that neuroinflammation and mitochondrial stress may play a role in COVID-19-induced neuronal damage
