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In summary, the harsh metabolic landscape of the TME, characterized by nutrient competition, accumulation of immunosuppressive metabolites, and dysregulated lipid and amino acid metabolism, severely impairs the function and fate of infiltrating immune cells, ultimately promoting tumor immune evasion and progression

Subject-reported sleep was improved in the vitamin D-treated groups after three months

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Cancers 12:164

3,4 The first study showed that adding PEA reduced the number of painful areas and decreased pain scores by 25%

These results are like others showing failure of vitamin C intake to improve metabolic disease-related complications or to protect against CVDs in various clinical settings (71, 72)