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Moreover, Nrf2 regulates heme oxygenase1 (HO1) and NQO1 to catalyze heme and quinone degradation.11 Phase III drug transporters extrude endogenous xenobiotics and conjugated metabolites out of cells, including multidrug resistanceassociated proteins (MRPs), Pglycoprotein (Ppg), and organic aniontransporting polypeptide (OATP).37 2.3