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4A,B, Erk1/2 activation occurred at 180 min in the presence of GSB-106, whereas Erk1/2 phosphorylation, induced by BDNF, registered in 30 min, reaching a maximum increase at 180 min

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In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation

J Biol Chem 247:31703175

Exposure to pristane for 12 or 24 weeks promoted macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, as well as hypercytokinemia of IFN-, TNF-, IL-4, and IL-6

Redox imbalance caused by microsomal glutathione S-transferase 1 (MGST1) knockout effectively impaired melanoma metastasis [36]