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We then integrate these principles with mechanisms of molecular damage and adaptive responses (e.g., mitochondrial and ER unfolded protein responses, autophagy and DNA repair)

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IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients

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Similar content being viewed by others Introduction Melasma is a common acquired hyperpigmentary disorder and the treatment remains challenging 1

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Comparison among mammalian GPxs 14 As discussed above, the active sites of the mammalian GPxs 14 are highly conserved

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The cellular concentration of GSH, therefore, is regulated by a complex process of precursor amino acid transport across cell membranes, intracellular synthesizing enzymes, feedback regulation, and intracellular GSH complexing via conjugation of GSH with a variety of electrophilic compounds through GSH transferase reactions

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