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The classic lesion is well-demarcated with smooth borders (coast of California) and homogeneous in appearance

Thus, GPx-1-deficient mice have been found to be more sensitive to neuronal injury in response to a variety of neurotoxins, including the mitochondrial toxins

Recently, the neuroprotective and tolerogenic LIF was attached to CD4 + T cells and loaded in PLGA NPs for transporting across the BBB

Concurrently, regulatory agencies are beginning to issue more detailed guidelines on quality and labeling requirements, and are exploring specific pathways for LBPs and engineered strains